GSE149512

Human Testis Development Atlas

This atlas presents the normal developmental subset of GSE149512, spanning childhood, puberty and adulthood. It supports exploration of germ cell differentiation and the changing…

GEO accession
GSE149512
Species
Homo sapiens
Tissue
Testis
Assay
Single-cell RNA-seq
Cells
61,605
Samples
10
Genes
44,453
Cell metadata fields
2

Atlas schematic preview

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Figure legend：Schematic of tissue and cell populations.

Dataset Description

This atlas presents the normal developmental subset of GSE149512, spanning childhood, puberty and adulthood. It supports exploration of germ cell differentiation and the changing testicular somatic environment, including Sertoli, Leydig and peritubular myoid cells.

Ten normal developmental samples. This atlas shares source material with the human germ cell lineage and NOA atlases.

Annotation notes

LZ009: 5 years old; LZ005: 8 years old.

Associated Publication

[1]

Zhao L, Yao C, Xing X, Jing T, Li P, Zhu Z, et al. Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells. Nat Commun. 2020;11(1):5683. doi: 10.1038/s41467-020-19414-4. PMID: 33173058.

PubMed ↗ · DOI ↗

Data SourceGSE149512

NCBI GEO GSE149512

View GEO record ↗

Data Preview

Five deterministically sampled cells are shown for a quick structural check.

Row Cell ID UMAP 1 UMAP 2 Cell group
1 LZ005_AAACGAAAGGGCGAGA -6.730 -3.066 LC
2 LZ007_CACATGACAATCGAAA 5.609 -5.282 SPT
3 LZ007_ATCATTCTCTATCGGA 6.750 4.627 SPG
4 LZ016_AACAAGAGTAACATAG 10.790 -3.503 SPC
5 LZ015_833358 -5.271 1.312 LC