GSE149512

Human Testis Non Obstructive Azoospermia Atlas

This atlas compares adult testes with normal spermatogenesis and non-obstructive azoospermia in GSE149512. It includes idiopathic NOA, Klinefelter syndrome and AZFa deletion,…

GEO accession
GSE149512
Species
Homo sapiens
Tissue
Testis
Assay
Single-cell RNA-seq
Cells
62,163
Samples
12
Genes
44,453
Cell metadata fields
3

UMAP preview

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Dataset Description

This atlas compares adult testes with normal spermatogenesis and non-obstructive azoospermia in GSE149512. It includes idiopathic NOA, Klinefelter syndrome and AZFa deletion, enabling exploration of germ cell loss and changes in the testicular somatic environment.

Five adult controls and seven NOA samples: 27,597 Normal, 20,865 iNOA, 8,267 KS and 5,434 AZFa_Del cells. Adult controls overlap the developmental atlas.

Associated Publication

[1]

Zhao L, Yao C, Xing X, Jing T, Li P, Zhu Z, et al. Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells. Nat Commun. 2020;11(1):5683. doi: 10.1038/s41467-020-19414-4. PMID: 33173058.

PubMed ↗ · DOI ↗

Data SourceGSE149512

NCBI GEO GSE149512

View GEO record ↗

Data Preview

Five deterministically sampled cells are shown for a quick structural check.

Row Cell ID UMAP 1 UMAP 2 Cell group
1 LZ002_AAAGCAATCTGCGACG -5.188 -3.842 LC
2 LZ002_ATTGGTGTCGCACTCT -0.303 -7.998 PTM
3 LZ014_464908 7.826 -6.233 SPT
4 LZ004_TACGGGCAGAAGATTC 0.874 6.198 SC
5 LZ019_539412 -4.494 1.196 LC