GSE117403 / GSE141445

Human Prostate Cancer Atlas

This atlas combines normal prostate and prostate tumor single-cell data from GSE117403 and GSE141445. It includes luminal, basal, specialized epithelial, stromal and immune…

GEO accession
GSE117403 / GSE141445
Species
Homo sapiens
Tissue
Prostate
Assay
Single-cell RNA-seq
Cells
16,893
Source groups
16
Genes
33,694
Cell metadata fields
3

Atlas schematic preview

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Figure legend：Schematic of tissue and cell populations.

Dataset Description

This atlas combines normal prostate and prostate tumor single-cell data from GSE117403 and GSE141445. It includes luminal, basal, specialized epithelial, stromal and immune populations. Comparisons between normal and tumor groups should account for their different source studies and sampling designs.

Three normal source groups and thirteen tumor source suffixes, totaling sixteen source groups. These are not necessarily independent donors. The atlas contains 8,892 Normal and 8,001 PC cells.

Associated Publication

[1]

Henry GH, Malewska A, Joseph DB, Malladi VS, Lee J, Torrealba J, et al. A Cellular Anatomy of the Normal Adult Human Prostate and Prostatic Urethra. Cell Rep. 2018;25(12):3530-3542.e5. doi: 10.1016/j.celrep.2018.11.086. PMID: 30566875.

PubMed ↗ · DOI ↗

[2]

Chen S, Zhu G, Yang Y, Wang F, Xiao YT, Zhang N, et al. Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression. Nat Cell Biol. 2021;23(1):87-98. doi: 10.1038/s41556-020-00613-6. PMID: 33420488.

PubMed ↗ · DOI ↗

Data SourceGSE117403 / GSE141445

NCBI GEO GSE117403 / GSE141445

View GEO record ↗

Data Preview

Five deterministically sampled cells are shown for a quick structural check.

Row Cell ID UMAP 1 UMAP 2 Cell group
1 CTTACCGAGTGCGTGA-4_1 9.028 6.384 FB
2 TAGACCACATCCGTGG-2_2 -6.194 3.474 LE
3 TAAGTGCCAGGAATGC-3_3 -3.180 -6.830 KRT13+OE
4 AGCGTCGTCTAACTCT.11 -6.375 0.859 LE
5 ACTGTCCTCCGTAGTA.8 -3.722 -1.054 SCGB1A1+OE